Building a comprehensive 340B strategy

The 340B Drug Pricing Program, established by Congress in 1992, was designed to help eligible healthcare organizations stretch scarce federal resources in order to serve more patients and deliver more comprehensive care. Over time, 340B has evolved into a powerful tool that can boost patient outcomes while supporting a hospital’s financial sustainability

Here are four strategic pillars to consider as you transform your 340B program into a driver of community health.

1. Establish a dedicated 340B management team

Successful 340B programs require continuous oversight and deep program knowledge. Establish a dedicated management team to ensure compliance, track performance, and adapt quickly to regulatory changes.

2. Expand pharmacy services to improve margins

Integrate 340B savings with on-campus retail and specialty pharmacy services to increase patient care access and improve the patient experience while strengthening your hospital’s 340B revenue stream.

3. Optimize the revenue cycle through pharmacy

You should embed your pharmacy services within your hospital’s revenue cycle. By capturing and processing all eligible prescriptions, you can maximize 340B savings, enhance treatment workflows, and drive better clinical and financial outcomes.

4. Strategic reinvestment: A pharmacy-led readmission initiative

Manufacturer-imposed limitations and compliance requirements continue to challenge 340B providers. Staying informed and proactive in addressing these barriers is essential for maintaining access to discounted medications and preserving program integrity.

Final thoughts

In a changing healthcare landscape, leveraging the full potential of 340B is essential for hospitals committed to making a difference in the communities they serve. It provides hospitals with a pathway to expand services, improve care, and ensure long-term viability.

By adopting a thoughtful, integrated strategy that includes dedicated program leadership, pharmacy alignment, and financial optimization, you can turn your 340B program into a high-impact engine for community health.

Further reading

• Stretching Scarce Federal Resources: How Conway Medical Center Is Redefining 340B’s Impact
• Use AI to optimize your health system’s 340B program
• The future of 340B: What health system leaders need to know in 2025 and beyond
• How to align 340B with value-based care: A framework for success

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